For me, it would be GLaDOS.
Portal 2 spoiler
She deleted the one remaining human part of herself because it was just too much to deal with. She releases you at the end of Portal 2 as a path of least resistance measure because “killing you is hard.”
What about you, what is your favorite media villain?
Ketheric Thorm from Baldurs Gate 3. He has one of the coolest character introductions ever. Honestly I felt kind of bad for him learning his story. Also JK Simmons is one of my favorite actors.
“Try again” axe drop